Advertisement

Cancer Research ranks 17th with an Impact Factor of 9.130!

From the Current Issue

  • Tumor Biology and Immunology | AuthorChoice
    IL1 Receptor Antagonist Controls Transcriptional Signature of Inflammation in Patients with Metastatic Breast Cancer
    Te-Chia Wu, Kangling Xu, Jan Martinek, Robyn R. Young, Romain Banchereau, Joshy George, Jacob Turner, Kyung In Kim, Sandra Zurawski, Xuan Wang, Derek Blankenship, Hannah M. Brookes, Florentina Marches, Gerlinde Obermoser, Elizabeth Lavecchio, Maren K. Levin, Sookyoung Bae, Cheng-Han Chung, Jennifer L. Smith, Alma-Martina Cepika, Kyp L. Oxley, George J. Snipes, Jacques Banchereau, Virginia Pascual, Joyce O'Shaughnessy and A. Karolina Palucka
    Cancer Res September 15 2018 78 (18) 5243-5258; DOI:10.1158/0008-5472.CAN-18-0413

    IL1β orchestrates tumor-promoting inflammation in breast cancer and can be targeted in patients using an IL1 receptor antagonist.

  • Matrix Stiffening and EGFR Cooperate to Promote the Collective Invasion of Cancer Cells
    Tumor Biology and Immunology
    Matrix Stiffening and EGFR Cooperate to Promote the Collective Invasion of Cancer Cells
    Eloise M. Grasset, Thomas Bertero, Alexandre Bozec, Jonas Friard, Isabelle Bourget, Sabrina Pisano, Margaux Lecacheur, Majdi Maiel, Caroline Bailleux, Alexander Emelyanov, Marius Ilie, Paul Hofman, Guerrino Meneguzzi, Christophe Duranton, Dmitry V. Bulavin and Cedric Gaggioli
    Cancer Res September 15 2018 78 (18) 5229-5242; DOI:10.1158/0008-5472.CAN-18-0601

    This work demonstrates that calcium channels blockers verapamil and diltiazem inhibit mechano-sensitization of EGF-dependent cancer cell collective invasion, introducing potential clinical strategies against stromal-dependent collective invasion.

  • Targeting USP7 Identifies a Metastasis-Competent State within Bone Marrow–Resident Melanoma CTCs
    Translational Science
    Targeting USP7 Identifies a Metastasis-Competent State within Bone Marrow–Resident Melanoma CTCs
    Monika Vishnoi, Debasish Boral, Haowen Liu, Marc L. Sprouse, Wei Yin, Debalina Goswami-Sewell, Michael T. Tetzlaff, Michael A. Davies, Isabella C. Glitza Oliva and Dario Marchetti
    Cancer Res September 15 2018 78 (18) 5349-5362; DOI:10.1158/0008-5472.CAN-18-0644

    These findings provide insights into mechanism of melanoma recurrence and propose a novel approach to inhibit systematic metastatic disease by targeting bone marrow-resident tumor cells through pharmacological inhibition of USP7.

See the Table of Contents

Recent Reviews

OnlineFirst Articles

Load more
Advertisement

Back to top