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Fig. 3. Effect of SU5416 and SU6668 on PCNA expression and apoptosis of endothelial and tumor cells. Immunohistochemical staining for PCNA and immunofluorescent staining for TUNEL, with or without staining for CD31, were performed in tumor-bearing liver sections to quantify and compare tumor cell proliferation, endothelial cell apoptosis, and tumor cell apoptosis. Bars, SE. *, P < 0.001 versus control; {ddagger}, P < 0.048 versus SU5416.