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Cell Fusion as a Hidden Force in Tumor Progression

Department of Molecular Biology, Princeton University, Princeton, New Jersey

Requests for reprints: Yibin Kang, Department of Molecular Biology, Washington Road, LTL 255, Princeton University, Princeton, NJ 08544. Phone: 609-258-8834; Fax: 609-258-2340; E-mail: ykang{at}princeton.edu.

Cell fusion plays an essential role in fertilization, formation of placenta, bone and muscle tissues, immune response, tissue repair, and regeneration. Increasing recognition of cell fusion in somatic cell dynamics has revitalized the century-old hypothesis that cell fusion may contribute to the initiation and progression of cancer. In this review, we discuss findings from experimental and clinical studies that suggest a potentially multifaceted involvement of cell fusion in different stages of tumor progression, including aneuploidy and tumor initiation, origin of cancer stem cells, multidrug resistance, and the acquisition and diversification of metastatic abilities. [Cancer Res 2009;69(22):8536–9]

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