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Isolation of Fungi from Transplanted, Chemically Induced and Spontaneous Tumors

I. General Considerations^*

(From the Lankenau Hospital Research Institute and the Institute for Cancer Research, Philadelphia, Pennsylvania)

The microscopic study of smear preparations of tumor tissue, prepared by a variety of cytological technics, has revealed the presence of inter- and intracellular fungal structures. Spores and developing conidia may be easily mistaken, in preparations made by routine histological technics, for lymphocytes and other blood cells.

Mycelial forms of the fungi were readily isolated from transplanted, induced, and spontaneous tumors of the mouse and from human tumors. Fungi Imperfecti related to the Blastomycete group have been isolated from all types of tumor, including human neoplasms, and from mouse leukemias. In mice, a second form of fungus, apparently specific for the host strain, is frequently encountered.

^* Supported in part by an institutional grant from the American Cancer Society, Inc.

Received 10/10/49.

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