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The Effect of Nitrofurazone on Growth of Fibrosarcoma in Mice^*

(From the Department of Surgery, Maimonides Hospital, the State University Medical Center at New York, and the Department of Bacteriology, School of Medicine, University of Missouri, Columbia)

Furacin suspended in peanut oil, injected subcutaneously, retarded the growth of fibrosarcoma S-13 in C3H mice of the Andervont subline. The life span of the mice was approximately doubled by this treatment (from 21 to 40 days). Microscopic examination of the furacin-treated tumors revealed increased cellular degeneration, with lessened mitotic activity. Hypertrophy of the adrenal cortex and atrophy of the testes and ovaries have also been observed in the furacin-treated animals.

^* This work was supported by grants from Eaton Laboratories, Inc., Norwich, N.Y., Research Council, University of Missouri, and the Public Health Service.

Received 5/ 4/50.

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