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Citric Acid Metabolism in Carcinogenesis and Its Relationships to Calcium Metabolism^*

(From the Department of Anatomy, Washington University School of Medicine, St. Louis, Missouri)

1. A method for the determination of citric acid in tissues has been outlined.

2. It was found that each normal tissue examined had a content of citric acid characteristic for that tissue, while the tumors, regardless of derivation or source, showed very similar levels of citric acid.

3. An attempt has been made to correlate the results in terms of calcium and carbohydrate metabolism and cell ratios.

^* Aided by grants from the National Cancer Institute, the Charles F. Kettering Foundation, and the American Cancer Society.

Received 5/31/50.