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Investigation of the Nucleic Acids of Viscera and Tumor Tissue from Animals Injected with Radioactive 8-Azaguanine^*

Jack H. Mitchell, Jr., Ph.D., Howard E. Skipper, Ph.D. and Leonard L. Bennett, Jr., Ph.D.

(From the Organic and Biochemistry Division, Southern Research Institute, Birmingham, Alabama)

1. Radioactive carbon from carbon-labeled 8-azaguanine, at 6 and 24 hours after injection, is found in higher concentrations in the nucleic acid fractions of normal viscera and of Eo771 tumor tissue than in the tissues from which the nucleic acids were isolated.

2. The nucleic acid fraction from Eo771 tumor tissue is no higher in radioactivity than the nucleic acid fraction from normal visceral tissue.

3. 8-Azaguanine has been shown to be present in the purines isolated from the ribosenucleic acid fraction of visceral tissue of animals injected with radioactive 8-azaguanine.

^* This work was supported by grants from the American Cancer Society upon recommendation of the Committee on Growth; Mr. Ben May, Mobile, Alabama; the Institute Sponsored Research Fund, Southern Research Institute; and the Isotopes Division, Atomic Energy Commission.

Acknowledgment for technical assistance is due Mrs. Constance Nolan, Miss Margaret Ann Newton, Mrs. Juanita Chapman, Miss Martelia Bell, and Miss Linda Simpson.

Received 6/15/50.