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Heterologous Growth of Sarcoma 180 with Progression to Death of Hosts^*

(From the Division of Experimental Chemotherapy, Sloan-Kettering Institute for Cancer Research, New York 21, N.Y.)

It has been possible to make serial passages of the mouse tumor Sarcoma 180 in the newborn rat by utilizing the intraperitoneal route of inoculation. Subcutaneous inoculations of newborn rats and a transplant of the same tumor in older animals generally failed to grow or regressed after a short period. When inoculated into 1-2-day-old rats, the Sarcoma 180 generally brought about the death of the animal in a week, often with widespread metastases.

^* This research was supported wholly by a grant from the American Cancer Society.

Received 3/24/50.