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Estrone Conversion Capacity of Blood of Postmenopausal Women with Carcinoma of the Breast^*

(From the Worcester Foundation for Experimental Biology, Shrewsbury, Massachusetts, and the Department of Physiology, Tufts Medical School, Boston, Massachusetts)

A semi-quantitative test of the estronase concentration in human blood has been described. The test was employed in a comparison of the titer of normal postmenopausal blood and that of postmenopausal women with carcinoma of the breast. The data show that the postmenopausal women with carcinoma of the breast can be expected to have a significantly higher blood titer of the enzyme than do normal postmenopausal women.

^* Supported in part by grants from the American Cancer Society (Massachusetts Division, Inc.), and the Public Health Service, Grant No. C 321.

Received 5/31/50.