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Attempts To Produce Gastric Carcinoma Experimentally in a Gastric Ulcer^*

(From the Department of Clinical Science, University of Illinois College of Medicine, Chicago, Illinois)

A chronic gastric ulcer was produced in rabbits by excision or by bilateral vagotomy, and then methycholanthrene was fed for periods ranging from 3 to 18 months (one for 3.3 years and 30 for from 8 to 18 months) with the idea that a cancer might occur in the ulcer. A cancer was not observed, although cystic changes in and atrophic gastritis of the gastric mucosa and epithelial inclusions in papillomatous scars of healed ulcers were observed.

^* Assisted in part by a grant-in-aid from the National Cancer Institute of the Public Health Service.

Received 6/13/50.