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Induced Tumors of the Parotid Gland^*

(From the Department of Pathology, School of Dentistry, St. Louis University, St. Louis, Mo.)

1. Rabbits seem to possess an unusual resistance to the production of induced salivary gland tumors.

2. Of the mice employed, strain C was the most responsive; strains A, C57 black, and AK, in that order, were less responsive.

3. Once the neoplasm had been induced, the strain of the mouse did not influence the type of tumor produced.

4. The adenoacanthoma with its many varied patterns was the most frequently produced tumor.

5. Related tumors were adenoma, papillary cyst adenoma, undifferentiated carcinoma, and giant-cell carcinoma. Metastases into the lungs occurred.

6. The site of origin of the initial metaplastic change and of the subsequent neoplasm was the pluripotential cuboidal epithelial cell of the intercalated ducts. These ducts may be regarded as proliferation centers.

^* This project was supported by a grant from the National Cancer Institute of the National Institutes of Health, Public Health Service.

Received 7/ 9/50.