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The Role of Cellular Fractions in the Transplantation of the Walker Rat Carcinoma 256^*

(From the University of Chicago Toxicity Laboratory, University of Chicago, Chicago, Ill.)

Five- and 10-gm. portions of a Walker rat carcinoma 256 were fractionated by ultra-centrifugation into subcellular components immediately after dissection from three donor rats. Only the fractions containing intact cells produced tumors when injected subcutaneously into rats. The mitochondria fraction which was known to contain nuclei, the microsome fraction, and the supernatant of the microsomes produced no tumors over a 6-week observation period.

^* The work described in this paper was conducted at the University of Chicago Toxicity Laboratory under a research contract supported by the Atomic Energy Commission and administered through the Medical Division, Chemical Corps, U.S. Army. Under the terms of the contract neither the Atomic Energy Commission nor the Army Chemical Corps is responsible for the opinions or conclusions of the authors.

Received 9/14/50.