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Liver Catalase of Tumor-bearing and Leprous Rats^*

(From the Departments of Biochemistry and Surgery, School of Medicine and Dentistry University of Rochester, Rochester, New York)

1. In rats with advanced murine leprosy, the liver catalase activity, based on the activity of enzyme per unit dry weight of liver, is significantly lowered.

2. In surgically thyroidectomized rats and rats treated with thiouracil, no significant change in liver catalase activity was noted.

3. A lowering of the activity of catalase, per unit dry weight of liver, was found in tumor-bearing rats. This finding was in agreement with Green-stein.

4. The per cent decrease of liver catalase activity in tumor-bearing rats, as compared to normal rats, was found to be of the same magnitude, whether measured by titrimetric or manometric methods.

^* We wish to thank Dr. G. B. Mider, who suggested this work, for his helpful advice and constructive criticism of our paper. We are indebted to citizens of Monroe County, New York, and to the Donner Foundation, who provided funds to support this work. We also wish to express appreciation to Dr. C. M. Carpenter and Dr. Lief G. Suhrland who furnished the leprous rats.

Received 9/23/49.