This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Goldfeder, A. Articles by Lane, M. Search for Related Content PubMed Articles by Goldfeder, A. Articles by Lane, M.

The Relative Metabolism in vitro of Analogous Mammary Tumors^*

I. Oxygen Uptake and Aerobic Glycolysis of Mammary Tumors Autogenous to dba and C₃H Strains of Mice^,

(From the Cancer Research Laboratory, Department of Hospitals, City of New York, and from the Department of Biology, Graduate School of Arts and Science, Washington Square College, New York University, New York)

The relative rates of respiration and aerobic glycolysis of mammary adenocarcinomas which arose in two inbred strains of mice, dba and C₃H, have been considered in the present study. The mammary tumor of the C₃H strain was found to have an average Q_o2 of -3.6 in 100 per cent oxygen, an average aerobic glycolysis (Q) of 8.5, and an average R.Q. of 0.86. The mammary tumor (dbrB) of the dba strain proved to have an average Q_o2 of -5.9, an average aerobic glycolysis of 24.3, and an average R.Q. of 0.80.

The relatively greater metabolic activity of the dbrB tumor corresponds to its relatively greater rate of growth as compared with that of the C₃H mammary tumor. The two mammary tumors, although histologically almost identical, proved to differ in their physiological characteristics: rate of growth, radiosensitivity, and metabolic activity. On the basis of observations made in previous and present studies on these mouse mammary tumors, it may be inferred that histological appearance alone is not a sufficient guide for the classification of tumors. Their physiological characteristics might be of greater value in such a classification.

The significance of the metabolic rate of these tumors in relation to their radiosensitivities is discussed.

Experiments to determine the metabolic properties of these tumors are now in progress.

^* Supported by grants obtained from the National Cancer Institute, U.S.P.H.S., and from the Damon Runyon Fund.

This paper was read by title at the 40th annual meeting of the American Association for Cancer Research, held at Detroit, in April, 1949.

Received 8/27/49.