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Effects of a Growth Inhibitor and Other Factors on the Tissue Cathepsins of Tumor-bearing Rats^*

(From the Toxicity Laboratory and the Department of Biochemistry, University of Chicago, Chicago)

1. The catheptic activity of rat spleen, liver, and tumor (Walker carcinoma 256) has been determined under the influence of a variety of treatments.

2. In confirmation of earlier work, it is shown that the presence of this tumor causes an increased catheptic activity in the host tissues.

3. Treatment of tumor-bearing animals with 4-dimethylaminostilbene hydrochloride, a potent tumor growth inhibitor, increases the catheptic activity of the tumor; it also decreases the catheptic activity of the spleen of the starved, tumor-bearing rat, and has a tendency, not mathematically significant, to decrease also the catheptic activity of the liver and spleen of the fed, tumor-bearing rat.

4. Starvation increases tumor catheptic activity.

5. Treatment of a starved animal with the stilbene compound further increases the tumor's catheptic activity.

^* The work described in this paper was done under contract between the Medical Division, Chemical Corps, U.S. Army, and the University of Chicago Toxicity Laboratory. Under the terms of the contract the Chemical Corps neither restricts nor is responsible for the opinions or conclusions of the authors.

Received 9/15/49.