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Heat Coagulation of Serum in Cancer: A Method Applicable to Very Small Quantities of Serum

(From the Nassau Hospital, Mineola, N.Y.)

A method is described for measuring, as the extinction coefficient per gram of protein, the opacity developed by serum when heated under standard conditions. The values obtained are highly correlated with the iodoacetate index of Huggins, Miller, and Jensen, a decreased opacity corresponding to a decreased coagulability in cancer and other conditions in man. The quantities of serum required are so small that the method can be applied to small experimental animals; a similar decrease in opacity per gram of protein occurs in the tumor-bearing rat but has not been observed in the tumor-bearing mouse, largely because the opacity per gram of protein developed in heated mouse serum varies very widely.

Received 10/28/49.