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Citric Acid Content of Normal and Tumor Tissues In Vivo following Injection of Fluoroacetate^*

(From the McArdle Memorial Laboratory, Medical School, University of Wisconsin, Madison 6, Wis.)

1. Marked accumulations of citrate occurred in most normal rat tissues within 1 hour after the injection of a lethal dose of fluoroacetate (5 mg/kg). Essentially no further increase occurred after the first hour.

2. Under the same conditions, no citrate accumulation occurred in tumor tissues or in normal liver. The lack of citrate accumulation in the liver may result from the presence of an alternative pathway of metabolism that leads to acetoacetate; but, in the case of the tumor tissue, the data are regarded as further evidence for a decreased ability to effect the Krebs condensation.

^* This work was supported by a grant from the U.S. Public Health Service and by the Jonathan Bowman Fund for Cancer Research.

Received 2/ 2/50.