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The Effect of Methylcholanthrene on the Genital Tracts of Rabbits and Dogs as Revealed by Biopsies and Exfoliative Cytology^{* ,}

(From the University of Colorado School of Medicine, Department of Obstetrics and Gynecology)

An unsuccessful attempt was made to induce malignant tumors by methylcholanthrene in the cervices and vaginas of rabbits and dogs. The vaginas of rabbits were exposed to the carcinogen for as long as 76 weeks. The uterine cervices of the dogs were exposed to the same substance for as long as 190 weeks. Apparently, the genital tracts of these animals are very resistant to methylcholanthrene. Since no tumors were produced, it was impossible to study the histogenetic evolution of artificially produced tumors.

^* Abridgement of thesis submitted by W. C. Pallas to the faculty of the Graduate School of the University of Colorado in partial fulfilment of the requirements for the degree of Master of Science in Obstetrics and Gynecology.

This project has been supported by grants from the U.S. Public Health Service and the Committee on Research and Creative Activities, University of Colorado.

Received 2/ 9/50.