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Plasma Antitrypsin Levels during Growth of a Rat Fibrosarcoma

(From the University of Texas, M. D. Anderson Hospital for Cancer Research, Houston, Tex.)

1. Antitrypsin levels and white blood counts at various stages in the growth of a rat fibrosarcoma are reported. There is an elevation of both during the period of most rapid growth.

2. Upon regression and after surgical removal of the tumor, the antitrypsin and white blood count decrease.

3. Control animals and those in which the implant does not take give essentially the same results, with no significant increase in either antitrypsin or white blood count.

4. Serosanguinous fluid accumulating in cysts in regressing tumors contains some antitrypsin but no white cells.

Received 2/18/50.