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The Significance of the Anterior Chamber in Tumor Transplantation

I. Transplantation of Mouse Neuroblastoma C1300 to Homologous Hosts^{* ,}

(From the Departments of Pathology, Veterans Administration Hospital, and University of Utah Medical School, Salt Lake City, Utah)

Mouse neuroblastoma C1300 was transplanted into the anterior chamber of 166 female mice of the C57 brown strain, and subcutaneously into 161. Comparable numbers of mice of each group were sacrificed serially, and the incidence of tumor growth was compared.

Tumor growth was significantly more frequent in mice in which the tumor had been transplanted to the anterior chamber. The tumor grew both within and beyond the anterior chamber.

Progressive tumor growth was significantly more frequent in mice with inoculations into the anterior chamber than in subcutaneously inoculated animals.

Gross metastases were not observed in these mice following tumor transplantation to the anterior chamber, in contrast to mice of the ABC strain in which this event almost invariably occurs following transplantation of this tumor to the anterior chamber.

^* This work was supported by a grant from the National Cancer Institute, U.S. Public Health Service.

Reviewed in the Veterans Administration and published with the approval of the Chief Medical Director. The statements and conclusions published by the authors are the result of their own study and do not necessarily reflect the opinion or policy of the Veterans Administration.

Received 3/18/50.