This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Moon, H. D. Articles by Evans, H. M. Search for Related Content PubMed PubMed Citation Articles by Moon, H. D. Articles by Evans, H. M.

Neoplasms in Rats Treated with Pituitary Growth Hormone

III. Reproductive Organs^*

(From the Institute of Experimental Biology and the Division of Anatomy, University of California, Berkeley, California; Division of Pathology, University of California Medical School, and Veterans Administration Hospital, San Francisco, California)

1. The long-term administration of pituitary growth hormone to fifteen normal female rats after their weight had reached a plateau resulted in atypical hyperplasia of small follicles in five rats and in solid tumors of the ovaries in two rats. No similar changes were present in the control rats.

2. The atypical hyperplasia of small follicles is considered an early stage in the development of granulosa-cell and interstitial-cell tumors of the ovary.

3. Fibro-adenomata of the mammary tissue occurred more frequently, were larger, and were often multiple in rats injected with growth hormone.

4. The above changes are regarded as the result of the chronic administration of pituitary growth hormone which causes a marked disturbance in the normal function of the pituitary gland.

^* Aided by grants from the Public Health Service RG-409 and C421; the Research Board of the University of California; the American Cancer Society, Inc., N.Y.; and the University of California Cancer Grant.

Received 4/10/50.

This article has been cited by other articles:

				G. M. Farris, G. K. Miller, G. K. Wollenberg, S. Molon-Noblot, C. Chan, and S. Prahalada Recombinant Rat and Mouse Growth Hormones: Risk Assessment of Carcinogenic Potential in 2-Year Bioassays in Rats and Mice Toxicol. Sci., June 1, 2007; 97(2): 548 - 561. [Abstract] [Full Text] [PDF]

				N. J. Barsoum, A. W. Gough, J. M. Sturgess, and F. A. de la Iglesia Morphologic Features and Incidence of Spontaneous Hyperplastic and Neoplastic Mammary Gland Lesions in Wistar Rats Toxicol Pathol, January 1, 1984; 12(1): 26 - 38. [Abstract] [PDF]

				S. W. Thompson and V. S. Rac Some Thoughts on Attempts to Correlate the Occurrence of Neoplastic and Non-Neoplastic Spontaneous Diseases in Laboratory Animals Toxicol Pathol, February 1, 1981; 9(2): 1 - 18. [PDF]

				G. L. Miller and J. Wynn Acromegaly, Pheochromocytoma, Toxic Goiter, Diabetes Mellitus, and Endometriosis Arch Intern Med, February 1, 1971; 127(2): 299 - 303. [Abstract] [PDF]

				M. T. Kahn and D. A. Mullon Pheochromocytoma Without Hypertension: Report of a Patient With Acromegaly JAMA, April 6, 1964; 188(1): 74 - 75. [Abstract] [PDF]

				C. H. Li Pituitary Growth Hormone as a Metabolic Hormone Science, April 13, 1956; 123(3198): 617 - 619. [PDF]

				CARCINOGENESIS AND THE PITUITARY GLAND JAMA, December 20, 1952; 150(16): 1604 - 1604. [Abstract] [PDF]

				H. D. Moon, M. E. Simpson, and H. M. Evans Inhibition of Methylcholanthrene Carcinogenesis by Hypophysectomy Science, September 26, 1952; 116(3013): 331 - 331. [PDF]