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Further Studies on Natural Antisheep Agglutinins in Mice of Inbred Strains^{* ,}

(From the Department of Pathology, Chicago Medical School, and the Mount Sinai Medical Research Foundation, Chicago, Illinois)

1. Natural antisheep agglutinins have been studied thus far in strains C57 black, C3H, dba, Marsh-albino, B alb C, Akm, C57 brown, and I.

2. The antisheep agglutinin in mice is not of the Forssman type.

3. Antigen of Forssman type was found in normal and neoplastic tissues of C3H, dba, and C57 black mice, independent of strain. The antigen was not present in the erythrocytes.

4. No relationship was noted between presence and titer of natural antisheep agglutinins and the incidence of spontaneous tumors in the strains studied.

5. The incidence and titer of antisheep agglutinin in C57 black mice showed a progressive rise from the fifth to the twelfth weeks of life.

^* Presented at the Forty-first Annual Meeting of the American Association for Cancer Research, Atlantic City, New Jersey, April 18, 1950.

This investigation was supported (in part) by a research grant from the National Cancer Institute, National Institute of Health, Public Health Service.

Received 5/ 6/50.