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Failure to Inhibit the Formation of Mammary Carcinoma in Mice by Intermittent Fasting^*

(From the Department of Cancer Research, Medical Research Institute, Michael Reese Hospital, Chicago 16, Illinois)

Intermittent caloric restriction—mice fasting twice weekly for 24 hours, followed by ad libitum feeding between fasting—did not materially affect the mean food consumption or mean body weight of dba female mice. There was no inhibitory effect on the incidence or rate of formation of spontaneous mammary carcinoma or on their subsequent growth.

^* This work was aided by a grant from Distillation Products, Inc., Rochester, N.Y.

Supported, in part, by the Michael Reese Research Foundation and the Foundation for Cancer Research, Chicago.

Received 5/29/50.