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The Development of Lymphatic and Myelogenous Leukemia in Wistar Rats Following Gastric Instillation of Methylcholanthrene

(From the Samuel S. Fels Research Institute, Temple University School of Medicine, Philadelphia, Pa.)

Six cases of lymphatic and two cases of myelogenous leukemia developed in a group of 59 Wistar rats under a variety of experimental conditions but in which all animals received methylcholanthrene by stomach catheter. The carcinogen was administered for periods of 1–14 months. From one case of lymphatic leukemia, the disease was transferred to two of three young colony rats by intraperitoneal injection of splenic cells suspended in normal saline.

Received 7/24/50.