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Test of Correlation between the Pink-Eye Gene and Susceptibility to Induced Fibrosarcoma in Mice^*

(From the Department of Anatomy, Yale University School of Medicine, New Haven, Conn.)

A mutation at the pink-eye locus occurred in the descendants of dark-eyed mice injected with methylcholanthrene (mutation = P to p). Mice showing the recessive mutation and their dark-eyed sibs continued to develop (a) fibrosarcomas at the site of injection of methylcholanthrene, (b) lung adenomas, and (c) a mucosal lesion just anterior to the pylorus, at the same rate and incidence as mice of their dark-eyed ancestry.

^* This experiment has been made possible by grants from The Anna Fuller Fund, The Jane Coffin Childs Memorial Fund for Medical Research, and the Public Health Service, acting through the National Advisory Cancer Council.

Received 8/18/50.