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The Amino Acid Content of Certain Normal and Neoplastic Tissues^*

H. E. Sauberlich and C. A. Baumann

(From the Department of Biochemistry, College of Agriculture, University of Wisconsin, Madison 6, Wis.)

1. Samples of the Flexner-Jobling carcinoma, a sarcoma due to methylcholanthrene, hepatomas due to p-dimethylaminoazobenzene and m'-methyl-p-dimethylaminoazobenzene, and a spontaneous mammary fibrosarcoma were analyzed microbiologically for eighteen amino acids. Normal and pre-neoplastic tissues were analyzed by similar technics.

2. All eighteen amino acids were present in all the tumors. The amounts of the amino acids in most of the tumors were found to be very similar to those in the normal rat tissues analyzed, and to those in ordinary cuts of beef or pork. The mamary fibrosarcoma proved to be exceptional in that it contained very high amounts of glycine and proline, and in general it resembled the composition of a mixture of ordinary tumor tissue diluted with connective tissue.

^* Published with the permission of the Director of the Wisconsin State Agricultural Experiment Station. Supported in part by the Jonathan Bowman Cancer Fund and by the American Cancer Society through the Committee on Growth. Further details are recorded in a Ph.D. thesis entitled "Amino Acid Metabolism in Normal and Deficient Rats and Mice," H. E. Sauberlich, University of Wisconsin, July 1948. Presented in part to the American Association for Cancer Research, Detroit, April 1949. Mr. C. E. Blades assisted with certain of the determinations.

Now at the Department of Nutrition, Alabama Polytechnical Institute, Auburn, Alabama.

Received 9/13/50.