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Gastric Absorption of 3,4-Benzpyrene

II. The Significance of the Solvent for the Penetration of 3,4-Benzpyrene into the Stomach Wall

( Institute of Physical Chemistry, Åbo Akaderni, Åbo, and the Department of Anatomy and Roentgenology, Second Medical Clinic, University of Helsinki, Helsingfors, Finland)

The ability of various solvents to effect the penetration of 3,4-benzpyrene into the stomachs of mice and cats has been studied with the fluorescence microscope technic. Particular attention was paid to the significance of the lipophilic and hydrophilic properties of the solvent and of the balance between these properties.

The nature of the solvent is of little importance for penetration into the mouse forestomach.

For the penetration into the glandular mucosa of the stomachs of mice and cats the nature of the solvent is decisive. Substances with only lipophilic properties are unable to effect a penetration of BP. With substances possessing both lipophilic and hydrophilic properties a weak penetration is observed if the lipophilic properties predominate, and a strong penetration if the hydrophilic properties are predominant. The solvents of the last group are miscible with water. They include the polyethylene glycols and the association colloids (soaps and soaplike substances). Also, aqueous solutions of the association colloids are able to effect a penetration of BP. It is interesting to note that the bile salt solutions also possess properties which place them in the last group of solvents.

Received 5/10/51.