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The Effect of Tumor Implants on Chick Embryo Liver Catalase Activity^*

( College of Agriculture, University of California, Los Angeles, Calif.)

1. The effects of chorioallantoic implants of Brown-Pearce carcinoma and Jensen fibrosarcoma on liver catalase activity in the chick embryo have been studied.

2. The expression of liver catalase activity on a unit nitrogen basis shows decreased enzymatic activity, but the total quantity of liver catalase per unit weight of chick embryo plus tumor shows increased activity. The data suggest that tumor growth does not interfere with catalase synthesis.

3. Tumor growth stimulates incorporation of liver nitrogen to a greater extent than the increase in total liver catalase activity.

^* This investigation was aided by a grant from the University of California cancer research funds.

Received 6/ 8/51.