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A Comparison of Nitrogen Content of Lymph Nodes from Cancer and Noncancer Patients^*

( Departments of Medicine and Surgern and the Cancer Clinic of the George Washington University School of Medicine, Washington, D.C.)

1. Two hundred and ten lymph nodes were obtained from 28 surgical and 13 post mortem examinations. These nodes were examined biochemically for nitrogen content and histologically for verification of type tissue and presence of cancer.

2. There was no significant difference between the nitrogen content of metastatic and nonmetastatic nodes from cancer patients and that of nodes obtained from noncancer patients.

3. A consistent hyperplasia of lymphoid tissue observed in cancer patients suggests that this tissue shares to some extent with growing tumor the role of depleting other body tissues of their nitrogen stores.

4. Significant differences of nitrogen content were observed in lymph nodes from various sites.

^* Aided by grants from the National Cancer Institute, Public Health Service, and the American Cancer Society.

Received 4/18/51.