This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Twombly, G. H. Articles by Meisel, D. Search for Related Content PubMed PubMed Citation Articles by Twombly, G. H. Articles by Meisel, D.

The Distribution of Radioactivity in the Tissues of Mice Receiving Triphenylbromoethylene-Br^82*

( Department of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, New York, N.Y.)

1. Radioactive triphenylbromoethylene can be prepared with ease and with a high specific activity. Other investigators have shown that this compound is a potent synthetic estrogen, the brominated form being more estrogenic than triphenylethylene itself.

2. Because triphenylethylene on prolonged administration will cause the formation of Leydigcell tumors in the testes of male mice of the A, JK, C, and RIII strains and will not do so in other strains such as C57 black, it was thought worth-while to determine whether this difference in susceptibility to tumor formation could be related to a differing specific affinity of testicular tissues in various strains for the synthetic estrogen. Our observations that the radioactivity of the testes of four mouse strains, C57, A, RIII, and DBA, do not differ significantly after the injection of radioactive triphenylbromoethylene suggest that there is no selective absorption of this material by testicular tissue nor any difference in its local concentration in mice varying in their susceptibility to testicular tumor formation.

3. Repetition of the experiments of workers at the Curie Institute fails to confirm their observations that triphenylbromoethylene is concentrated to a high degree in the pituitary and adrenal glands.

^* This work was supported by grants from the National Cancer Institute, Public Health Service, and the Jane Coffin Childs Memorial Fund for Medical Research.

Received 5/25/51.