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Studies on the Metabolism, Distribution, and Excretion of 2-p-Toluenesulfonamidofluorene-S³⁵ in the Rat^{* ,}

Francis E. Ray and Mary F. Argus

( Cancer Research Laboratory, University of Florida, Gainesville, Fla.)

The distribution of radioactivity was studied in the organs and excreta of the rat at 24-, 54-, and 66-hour intervals following oral administration of a single dose of noncarcinogenic 2-p-toluenesulfonamidofluorene-S³⁵.

The amount found in the liver (1.0 per cent) and in the blood (100 µg/100 ml plasma) was comparable to the amounts of 2-acetylaminofluorene found in similar experiments. The noncarcinogenicity of 2-p-toluenesulfonamidofluorene, therefore, is not caused by insufficient concentration of the compound in the liver (a predominant site for 2-acetylaminofluorene-induced tumors) or in the blood. Over 90 per cent of the ingested dose was found to be eliminated unchanged through the gastrointestinal tract. Only 0.5 per cent of the radioactivity was found in the urine. All the compound accounted for in the urine was in the form of 2-aminofluorene. This minute quantity of 2-p-toluenesulfonamidofluorene which undergoes metabolism contrasts with the relatively large amount, approximately 30 per cent, of the carcinogenic 2-acetylaminofluorene appearing in the urine.

^* This work was supported by the Anna Fuller Fund and Public Health Cancer Research Grant C-1356.

Presented at the Forty-second Annual Meeting of the American Association for Cancer Research, Inc., Cleveland, Ohio, April 27–29, 1951 (Abstr., Cancer Research, 11:274, 1951).

With the technical assistance of Gilbert Bergquist and Shyne Marley.

Received 6/ 4/51.