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Studies on the Effect of 8-Azaguanine on Sarcoma 37 in Mice^{* ,}

( Department of Pharmacology, the George Washington University School of Medicine, Washington, D.C.)

1. Data are presented on the effect of single and multiple doses of 8-azaguanine on growth, morphology, and drug toxicity in normal and tumorbearing mice.

2. Multiple doses of 8-azaguanine produced a definite inhibition of growth and extreme cellular damage of Sarcoma 37.

3. Gross tumor damage was observed within 2–6 hours, with extensive morphological damage 24 hours after a single large dose of 8-azaguanine.

4. The number of mitotic figures in tumors after repeated doses of 8-azaguanine approached that of control tumors, whereas after a single large dose it was approximately one-fifth that seen in controls.

5. The drug was not completely destructive to this tumor. Progressively less effect on growth and morphology was seen on cessation of therapy.

6. No well defined separation of the tumor-inhibitory action of 8-azaguanine from systemic and morphological effects of the drug was apparent. The toxic action was similar in normal and tumorbearing mice. Multiple doses produced morphological spleen and adrenal damage.

^* This investigation was supported by a research grant from the National Cancer Institute, National Institutes of Health, Public Health Service.

The authors are indebted to Dr. H. George Mandel for the supply of 8-azaguanine and to the National Cancer Institute for the initial tumors and the mice employed in this investigation.

Received 6/30/51.