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The Distribution of Radioactivity in Mice Following Administration of 3,4-Benzpyrene-5-C¹⁴ and 1,2,5,6-Dibenzanthracene-9,10-C^{14* ,}

( McArdle Memorial Laboratory, The Medical School, University of Wisconsin, Madison 6, Wis.)

1. Radioactivity following intravenous injections of benzpyrene-5-C¹⁴ can be recovered quantitatively. No radioactivity appears in the respiratory CO₂. The compound and its metabolites are rapidly excreted into the bile, gastrointestinal tract, and feces. There is significant absorption into body fat.

2. The half-time of disappearance of radioactivity from benzpyrene-5-C¹⁴ from the site of subcutaneous injection in tricaprylin is 1 weeks. Excretion takes place through the feces.

3. The rate of disappearance of radioactivity from the site of a single application of benzpyrene-5-C¹⁴ has two phases, the half-times of which are approximately 1 days and 4 days.

4. These samples have been processed into the following fractions: neutral, acidic, loosely bound, and tightly bound to protein.

5. The significance of these results has been discussed.

^* An abstract of part of this report appeared in Cancer Research, 11:255, 1951.

This work was supported in part by a grant from the Wisconsin Section of the American Cancer Society.

Received 8/10/51.

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