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Nutritional Factors Affecting Tumor Penetrance in Drosophila melanogaster^{* ,}

( Washington Square College of Arts and Science and College of Dentistry, New York University, New York, N.Y.)

1. Crowding of itself as a physical stress does not influence tumor penetrance values in the ebony¹¹ pigmented tumor stock.

2. A nutritional deficiency created by the presence of increasing numbers of third instar larvae causes a reduction in tumor penetrance in younger larvae in the same culture.

3. It is suggested that this nutritional deficiency is in reality a yeast deficiency which is affecting the development of this ebony¹¹ tumor stock.

4. It is suggested that a nutritional critical period for tumor occurs before the third larval instar.

^* This investigation was supported by a research grant from the National Cancer Institute of the National Institutes of Health, Public Health Service.

The authors wish to thank Miss Brandt for her assistance in this work.

Received 5/28/51.

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