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Tocopherol in Tumor Tissues and Effects of Tocopherol on the Development of Liver Tumors^*

R. W. Swick, C. A. Baumann, W. L. Miller, Jr. and H. W. Rumsfeld, Jr.

( Department of Biochemistry, College of Agriculture, University of Wisconsin, Madison 6, Wis.)

Hepatomas induced by 3'-Me-DAB accumulated dietary -tocopherol more rapidly than did adjacent liver tissue; in depletion experiments hepatomas held tocopherol more tenaciously than normal tissue. The Jensen sarcoma, the Walker carcinoma, and the Flexner-Jobling carcinoma also absorbed tocopherol more rapidly than liver or muscle.

Dietary vitamin E decreased the incidence of hepatomas when large amounts of tocopherol were fed after the administration of 3'-Me-DAB. The vitamin increased tumor incidence slightly when fed between two periods of dye-feeding, while variations in the vitamin E intake made while the carcinogen was fed had little effect on final tumor incidence. Yeast protein fed during the intermediate period increased tumor incidence slightly whether the diet was high or low in tocopherol.

^* Published with the approval of the Director of the Wisconsin Agricultural Experiment Station. Supported in part by the Jonathan Bowman Cancer Fund and by a grant from the Committee on Growth, American Cancer Society.

Predoctoral Research Fellow, National Cancer Institute of the National Institutes of Health, Public Health Service, Federal Security Agency.

Received 8/20/51.