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Differences in Adrenal Responsiveness to Post-castrational Alteration as Evidenced by Transplanted Adrenal Tissue^*

( Division of Cancer Biology of the Department of Physiology, University of Minnesota Medical School, Minneapolis 14, Minn.)

By a series of experiments in which the adrenals of mice of inbred strains were transplanted into the common environment of adrenalectomized, gonadectomized F₁ hybrid animals, evidence has been obtained to indicate that the differences in the changes noted in the adrenals of different inbred strains of mice following gonadectomy are due mainly to differences in a responsiveness inherent in the adrenal tissue itself. When adrenals of A strain females (which show only minimal post-castrational changes) were transplanted to ovariectomized, adrenalectomized AZF₁ and ACEF₁ recipients, only 2 of 27 pairs became hyperplastic and produced detectable amounts of estrogen, whereas 26 of 42 grafts from donor Z, AZF₁, CE and ACEF₁ animals showed estrogen-producing hyperplastic or carcinomatous changes characteristic of the donor stock when transplanted to similar recipient animals. Similarly, Z adrenals, transplanted to ZCEF₁ hybrid animals, showed only hyperplastic changes, while CE or ZCEF₁ adrenals, when transplanted to genetically identical recipients, tended to become carcinomatous. Evidence was obtained, however, to indicate that the lesser tendency for the adrenals of orchiectomized Z male mice to show extensive hyperplastic changes is caused, most probably, by a difference in the response of the endocrine system of Z male and female animals following gonadectomy.

^* Assisted by grants from the Minnesota Cancer Society, the American Cancer Society upon recommendation by the Committee on Growth of the National Research Council, the Graduate School Research Fund of the University of Minnesota, and the National Cancer Institute of the National Institutes of Health, Public Health Service.

Received 8/25/51.

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