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Neoplasms in Rats Treated with Pituitary Growth Hormone

IV. Pituitary Gland^*

(From the Institute of Experimental Biology and the Division of Anatomy, University of California, Berkeley, Calif. Division of Pathology, University of California Medical School, and Veterans Administration Hospital, San Francisco, Calif.)

1. The pituitary glands of eleven rats injected for long periods with pituitary growth hormone and of fifteen controls injected with serum albumin were studied.

2. The acidophils of the anterior lobe of rats injected with growth hormone were smaller, less numerous, and contained fewer granules than those of the controls.

3. In three of eleven experimental rats, the basophils were increased in number and were similar to those occurring in castrate rats. In one of these rats there were numerous small basophilic adenomas. No similar changes occurred in the controls.

4. The adenomatous lesions of the anterior pituitaries were more numerous and were present in all of the eleven experimental rats which were studied. Similar lesions occurred in only eight of fifteen controls.

5. There was no correlation between specific pituitary lesions and the neoplasms of any given type occurring in the other organs.

6. No significant changes were noted in the pars intermedia or posterior lobe.

^* Aided by grants from the Public Health Service, RG-409 and C421; the Research Board of the University of California; the American Cancer Society, Inc., N.Y.; and the University of California Cancer Grant.

Received 10/ 3/50.

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