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Observations on Inhibition of Nucleic Acid Synthesis Resulting from Administration of Nitrogen Mustard, Urethan, Colchicine, 2,6-Diaminopurine, 8-Azaguanine, Potassium Arsenite, and Cortisone^*

(From the Organic and Biochemistry Division, Southern Research Institute, Birmingham, Ala.)

Using the technic of measuring the incorporation of formate carbon into nucleic acid purines of control and treated mice, data have been obtained which indicate that 2,6-diaminopurine, 8-azaguanine, cortisone, potassium arsenite, urethan, and nitrogen mustard inhibit nucleic acid synthesis in vivo. Benzene and colchicine have been relatively ineffective as inhibitors of nucleic acid synthesis under the conditions of these experiments.

^* This work was supported by the American Cancer Society, upon recommendation of the Committee on Growth of the National Research Council; the Research Fund of the Southern Research Institute; and Mr. Ben May, Mobile, Alabama. The authors wish to acknowledge the assistance of Miss Martelia Bell, Mrs. Juanita B. Chapman, and Mrs. Constance W. Nolan.

Received 10/21/50.