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Chemical Alterations Induced in Mouse Liver Following a Single Feeding of Carbon Tetrachloride^*

K. K. Tsuboi, R. E. Stowell and C. S. Lee

(From the Departments of Oncology and Pathology, University of Kansas Medical School, Kansas City, Kan.)

A general chemical characterization of the processes of liver degeneration and regeneration in mice following a single feeding of carbon tetrachloride has been presented. An increase in water and corresponding decreases in the level of liver neutral fat were found to accompany these processes. Considerable overlapping between the initial necrosis and subsequent regenerative process was evident. This resulted in a net increase in tissue bulk, due, presumably, to a restoration of tissue at a rate in excess of the removal of necrotic cells.

Studies on the distribution of nitrogen and phosphorus following carbon tetrachloride administration were presented and discussed in relation to the degenerative and regenerative processes.

Nucleic acid analyses indicated some loss of both pentose and desoxypentose types to be associated with liver necrosis, and considerable increases in both to be related to the restoration process. A comparison of the quantitative relationships between pentosenucleic acid, desoxypentosenucleic acid, and protein nitrogen levels at various intervals throughout the active phase of liver regeneration was presented and discussed.

^* Aided by grants from the Atomic Energy Commission and the National Cancer Institute.

Post Doctorate Research Fellow of the National Institutes of Health.

Received 9/ 5/50.