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Spontaneous Gastric Neoplasia in Mice of the Br-S Strain Incidence and Genetic Linkage Tests^*

(From the Department of Anatomy, Yale University School of Medicine, New Haven, Conn.)

The incidence of adenomatous neoplasia of the stomach in mice of a control sub-line of the inbred Br-S strain is reported, with reference to age, sex, and reproductive activity. The tumors rarely appear before the age of 6 months, but incidence in nonbreeders and in male breeders reaches a maximum at about a year. Breeder females show a marked lag and a much lower incidence at all ages. Size of tumor was somewhat correlated with age, although tumors of all sizes occurred at any age after about 10 months.

An outcross of this strain was made to obtain genetic linkage tests involving the genes a, b, d, and se, p, W, and a wavy-hair mutant. The incidence of gastric tumors was uniform in all classes, so that no linkage was indicated. This result contrasts with an earlier report of close linkage of b with the gastric tumor factor in tests with mice of the methylcholanthrene-treated line. Dominant inheritance with incomplete penetrance is indicated. In the present linkage-test population no relation of tumor incidence to body weight could be detected.

^* This experiment has been made possible by grants from the Public Health Service through the National Advisory Cancer Council, from The Jane Coffin Childs Memorial Fund for Medical Research, and from The Anna Fuller Fund.

Received 9/18/50.