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The Effect of Carcinogenic and Other Related Compounds on the Autoxidation of Carotene and Other Autoxidizable Systems

(From 106, Durham Road, Blackhill Co., Durham, Eng.)

The inhibition of the autoxidation of benzaldehyde by carcinogenic and other polycyclic hydrocarbons was confirmed, the more powerful carcinogens showing the greater effect. Under the influence of light, carotene in solvents in the presence of carbon tetrachloride or benzoyl peroxide became oxidized, an effect which was accelerated by many carcinogenic compounds. These results compared fairly well with those obtained when a silver bromide leuco dyestuff-impregnated filter paper was illuminated in the presence of a carcinogen, a colored spot appearing in many cases. It was suggested that the carcinogens might either act as pro-oxidants or anti-oxidants on specific animal enzyme systems.

Received 5/16/50.