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Influence of Diet on the Relative Incidence of Eye, Mammary, Ear-Duct, and Liver Tumors in Rats Fed 2-Acetylaminofluorene^*

R. W. Engel and D. H. Copeland

(From the Department of Animal Husbandry and Nutrition, Agricultural Experiment Station of the Alabama Polytechnic Institute, Auburn, Ala.)

Eye tumors, presumably originating in the harderian gland, were induced in 10 of 31 weanling rats fed 0.03 per cent 2-acetylaminofluorene on low fat diets for 7–8 months. Rats fed such diets made very poor weight gains. Attempts to induce eye tumors by feeding fat-containing diets ad libitum or at a restricted level of caloric intake were unsuccessful. Whether or not fat was present in the diet, mammary tumor induction was greatly decreased when the animals made poor weight gains. Conditions that favored mammary tumor induction, rapid growth, and high caloric intake appeared to decrease the induction of car-duct tumors. The type or quantity of diet consumed had little or no influence upon the induction of liver tumors. The results emphasize that the site of carcinogenic action of 2-acetylaminofluorene can be markedly influenced by the type and quantity of diet fed.

^* Published with the approval of the Director, Alabama Agricultural Experiment Station. This work was supported in part by grants from the Nutrition Foundation, Inc., New York City, from the American Cancer Society on the recommendation of the Committee on Growth of the National Research Council, and from the National Cancer Institute.

The authors are indebted to H. L. Stewart, Senior Pathologist, National Cancer Institute, for assistance in the interpretation of the microscopic material.

Received 10/23/50.