This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Silverstone, H. Articles by Tannenbaum, A. Search for Related Content PubMed PubMed Citation Articles by Silverstone, H. Articles by Tannenbaum, A.

The Influence of Dietary Fat and Riboflavin on the Formation of Spontaneous Hepatomas in the Mouse^{* ,}

(From the Department of Cancer Research, Medical Research Institute, Michael Reese Hospital, Chicago 16, Ill.)

Fat enrichment of the diet from about 2 per cent to nearly 20 per cent appeared to enhance the rate of formation of the spontaneous hepatoma of the C3H mouse. Reduced dietary riboflavin, on the other hand, had no direct influence on the incidence of such hepatomas. These findings are discussed in relation to the effects of the two dietary modifications on the genesis of other tumors of the mouse and the azo dye-induced liver tumor of the rat.

^* Presented, in part, at the Fifth International Cancer Congress, Paris, July 19, 1950.

This work was supported by a grant-in-aid from the American Cancer Society upon recommendation of the Committee on Growth of the National Research Council.

Supported, in part, by the Michael Reese Research Foundation and the Foundation for Cancer Research, Chicago.

Received 11/ 7/50.