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A Study on the Biologic Activity of a Transplanted Granulosa-Cell Tumor in Castrate C57 Mice^*

E. S. Crelin and J. T. Wolstenholme

(From the Department of Anatomy, Yale University School of Medicine, New Haven 11, Conn.)

1. A study of a transplanted granulosa-cell tumor in C57 castrate mice revealed a close correlation between the size and weight of the tumor and the quantity of estrogenic substance secreted.

2. It was estimated that a tumor weighing 4.30 gm. was secreting an amount of estrogenic substance with a stimulating effect approximately equal to that which 0.06 µg. of estradiol benzoate has on the vaginal mucosa of C57 mice.

3. A close correlation was also found to exist between the size and weight of the tumor and the severity of hypervolemic changes which occurred in the tumor-bearing mice.

^* This investigation was supported by a research grant from the Public Health Service.

Pre-doctorate research fellow, National Institutes of Health.

Post-doctorate research fellow, National Institutes of Health.

Received 11/17/50.