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A Study of the Metabolism of 20-Methylcholanthrene^*

(From the Department of Chemistry and the Radiation Laboratory of the University of California, Berkeley, Calif.)

20-Methylcholanthrene, labeled in the 11-position, has been administered subcutaneously in tricaprylin, and the distribution of radioactivity in the mice at various intervals has been determined. The radioactivity is eliminated mainly in the feces and to a lesser extent in the urine. An appreciable quantity of radioactivity is found in the tumors, part of which is the original hydrocarbon. There appears to be no localization of activity in any tissue or organ, the major amount remaining at the site of injection. The rate of elimination of C¹⁴ when introduced in methylcholanthrene appears to be about 3 times as rapid as when it is injected in the form of dibenzanthracene.

^* Presented at the Meeting of the American Association for Cancer Research, Inc., in Detroit, April, 1949.

Received 11/20/51.