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Delay of Methylcholanthrene Skin Carcinogenesis in Mice by 1,2,5,6-Dibenzofluorene^{* ,}

Byron Riegel, William B. Wartman, Willard T. Hill, Blanchard B. Reeb, Philippe Shubik and D. Warren Stanger

( Departments of Chemistry and Pathology, Northwestern University, Evanston and Chicago, Illinois)

1. The addition of 1,2,5,6-dibenzofluorene to methylcholanthrene delays skin carcinogenesis in mice.

2. Chrysene, fluorene, and 1,2,7,8-dibenzofluorene have no delaying effect on methylcholanthrene skin carcinogenesis in mice.

^* A preliminary report of this work was given at the meeting of the American Association for Cancer Research, Inc., Atlantic City, April, 1950, and at the Fifth International Cancer Congress, Paris, July, 1950.

This investigation was supported by a research grant from the National Cancer Institute of the National Institutes of Health, Public Health Service.

Present address: Chicago Medical School, 710 South Wolcott Avenue, Chicago 8, Ill.

Received 8/ 4/50.

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