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Increased Weight and Mitotic Activity in the Liver of Tumor-bearing Rats and Mice

( Departamento de Histofisiologia, Fundação Andréa e Virginia Matarazzo, Faculdade de Medicina, São Paulo, Brazil)

1. It was determined at autopsy of rats and mice bearing malignant tumors that a more or less close relation existed between the weight of the tumor and that of the liver, calculated on the basis of the ratio liver/body. Four kinds of malignant tumors were examined for their effect on the liver.

2. The increase in the weight of the liver of the tumor-bearing animal seems to be partly a consequence of mitotic activity induced by the presence of the tumor.

3. Unilateral nephrectomy in tumor-bearing C3H strain mice evoked an increase in mitoses. Mitoses appear throughout the whole liver, showing a great variety of abnormalities.

4. Control animals showed no trace of mitotic figures.

Received 8/20/50.