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The Distribution of S³⁵ from Labeled DL-Methionine in Mice Bearing Carcinoma of the Breast, Neoplasms of the Hematopoietic System, or Liver Abscesses^*

Henry S. Bloch, Claude R. Hitchcock, Arnold J. Kremen and Margaret J. Doran

( Department of Surgery, The Medical School, University of Minnesota, Minneapolis 14, Minn.)

The distribution of S³⁵ in mice bearing mammary carcinomas, lymphosarcomas, leukemias, or liver abscesses was studied 24 hours after an intraperitoneal injection of DL-methionine-S³⁵. The concentration of the isotope was highest in the intestinal wall and liver, lowest in muscle; it was considerably higher in protein fractions than in nonprotein fractions of the tissues. The concentration of S³⁵ in the wet tumor tissue was lower than that in the wet liver tissue of the same animals; but the concentration of the isotope in the proteins of lymphosarcomas was equal to or greater than that in the liver proteins from the same animals. The fact that the S³⁵ in wet lymphosarcoma tissue is lower than in wet liver tissue is probably due to the low protein content of lymphosarcomas. In contrast to that in tumors, the concentration of S³⁵ in liver abscesses was very low. On the premise that the concentration of a radioactive isotope in tumor tissue must be much higher than in other tissues of the body if the isotope is to be useful in the treatment of neoplastic diseases, the data reported here do not favor methionine-S³⁵ as a possible therapeutic agent for mammary carcinomas, lymphosarcomas, or leukemias.

^* This investigation was aided by the American Cancer Society Institutional Research Grant, No. INSTR-49.

Postdoctorate Research Fellow, National Cancer Institute, Public Health Service.

Received 11/ 1/50.