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The Development of Resistance to Reinoculation and of Circulating Cytotoxins in Response to Heterologous Ocular Tumor Transplantation in the Guinea Pig^*

( Divisions of Cancer Research and Ophthalmology, Department of Surgery, The University of Rochester School of Medicine and Dentistry, Rochester, N.Y.)

1. A state of resistance to the growth of an ocularly transplanted mouse tumor MT8 develops following either subcutaneous or intraocular transplantation of the same tumor in guinea pigs.

2. The resistant state to retransplantation in the eye is detectable at 7 days whether the original immunizing transplantation is made in the eye or subcutaneously.

3. Cytotoxins injurious to the cells of the same tumor growing in vitro are detectable at 7 days after transplantation either in the eye or subcutaneously; the cytotoxins are found in both eyes and in the blood plasma after a monocular or a subcutaneous tumor transplant.

4. It is concluded that the rate of development of these immunological reactions is not a critical factor in the superiority of the guinea pig eye as a transplantation site for these tumors.

^* These investigations were aided by funds contributed by eitizens of Monroe County, New York.

Received 12/ 4/50.