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Some Effects of Polysaccharide Preparations from Serratia marcescens and Aerobacter aerogenes on Cells in Tissue Culture^*

(The Lankenau Hospital Research Institute and The Institute for Cancer Research, Philadelphia 11, Pa.)

The effect of bacterial polysaccharide fractions isolated from Serratia marcescens and Aerobacter aerogenes has been studied on tissue cultures of normal chicken fibroblasts and of cells of Sarcoma 37 from mice. These fractions are not directly toxic for the tissues but may rather enhance the areal increase of both types of tissue.

^* This work was supported in part by Grants-in-Aid to Dr. Philip R. White and Dr. Hugh J. Creech from the American Cancer Society upon recommendation by the Committee on Growth of the National Research Council.

Received 12/23/50.